In the mid-1990s, University of Cambridge biochemists David Klenerman and Shankar Balasubramanian were trying to solve a fundamental problem: how to watch a single DNA polymerase molecule at work. Their approach used modified nucleotides, called reversible terminators, tagged with four different colors of fluorescent molecules. If one of these “terminators” was grabbed by the DNA polymerase and incorporated onto the replicating DNA strand, it would block the addition of any other bases until removed using a separate chemical reaction.
It’s not always easy spotting fake news, but one person who knows what it’s like to be the subject of it is singer Leigh-Anne Pinnock.
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▲当然，也不是没有瑕疵，仔细看上方悄悄多出了一个「满」字。
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